Hyperuricemia and psoriasis
Hyperuricemia is a condition in which there are chronically elevated levels of uric acid in the bloodstream. This uric acid can accumulate into joints and other spaces in the body, causing pain and inflammation, which the condition is then called gout. Treatment of hyperuricemia includes the use of purine analogs to suppress the immunity and analgesics to relieve pain associated with gouty arthritis.
Studies have shown that there is a possible etiologic relationship between the occurrence of hyperuricemia in patients with chronic plaque psoriasis. Higher amounts of urate crystals were found in samples of psoriatic plaque tissue, as compared to only occasional occurrence in normal skin surrounding the lesions. Patients with both psoriasis and hyperuricemia showed improvement of their psoriasis symptoms after treating their hyperuricemia. This may be due to the similar mechanisms of action of the drugs given to treat both psoriasis and hyperuricemia, and the autoimmune activity that occurs in psoriasis and gout.